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Estée Lauder supports innovative breast cancer research at ...
Oct 01, 2021 12:26 PM
Dr Sharissa Latham and PhD student Louise Baldwin awarded the annual Breast Cancer Award from Estée Lauder Companies.
Y2 receptors have been implicated in the development of obesity and are a potential target for obesity treatment due to their known role of inhibiting neuropeptide Y (NPY) induced feeding responses. However, the precise ...
Correlates of environmental factors and human plague: an eco...
May 08, 2013 12:46 PM
BACKGROUND: Human plague caused by Yersinia pestis remains a public health threat in endemic countries, because the disease is associated with increased risk of mortality and severe economic and social consequences. Duri...
Peptide YY 3-36 (PYY3-36) is known as a critical satiety factor that reduces food intake both in rodents and humans. Although the anorexic effect of PYY3-36 is assumed to be mediated mainly by the Y2 receptor, the involv...
Growth hormone and cortisol secretion after oral clonidine i...
May 08, 2013 12:44 PM
The purpose of this study was to evaluate oral clonidine for testing growth hormone (GH) responsiveness in healthy adults. Oral clonidine (0.15 mg) produced a satisfactory GH response (greater than 4 ng/ml from basal) in...
Familial idiopathic basal ganglia calcification (Fahr's dise...
May 08, 2013 12:45 PM
Idiopathic basal ganglia calcification (IBGC) is characterised by radiological, neurological, cognitive and psychiatric abnormalities. The associations between these abnormal phenotypes and abnormal genes remain unclear ...
Mortality risk associated with low-trauma osteoporotic fract...
May 08, 2013 12:46 PM
CONTEXT: There are few data on long-term mortality following osteoporotic fracture and fewer following subsequent fracture. OBJECTIVES: To examine long-term mortality risk in women and men following all osteoporotic frac...
The transition from fetal growth restriction to accelerated ...
May 08, 2013 12:46 PM
A world-wide series of epidemiological and experimental studies have demonstrated that there is an association between being small at birth, accelerated growth in early postnatal life and the emergence of insulin resista...
The effect of acute inhibition of both mTORC1 and mTORC2 on metabolism is unknown. A single injection of the mTOR kinase inhibitor, AZD8055, induced a transient, yet marked increase in fat oxidation and insulin resistanc...
Impaired B cell development in the absence of Kruppel-like f...
May 08, 2013 12:46 PM
Kruppel-like factor 3 (Klf3) is a member of the Klf family of transcription factors. Klfs are widely expressed and have diverse roles in development and differentiation. In this study, we examine the function of Klf3 in ...
While anxiety disorders are the brain disorders with the highest prevalence and constitute a major burden for society, a considerable number of affected people are still treated insufficiently. Thus, in an attempt to ide...
Crystallization and preliminary X-ray diffraction studies of...
May 08, 2013 12:45 PM
Human synovial type IIA phospholipase A(2) (sPLA(2)-IIA) has been implicated in the pathogenesis of a number of inflammatory diseases and is a target for the development of therapeutically useful inhibitors. Biochemical ...
Retinoic acid acts synergistically with 1,25-dihydroxyvitami...
May 08, 2013 12:44 PM
Although retinoic acid has been shown to inhibit proliferation in human breast cancer cells, the mechanisms by which these effects are mediated are not known. Since several steroid hormones and their synthetic antagonist...
Amelioration of lipid-induced insulin resistance in rat skel...
May 08, 2013 12:46 PM
AIMS/HYPOTHESIS: To determine if acute overexpression of peroxisome proliferator-activated receptor, gamma, coactivator 1 beta (Pgc-1beta [also known as Ppargc1b]) in skeletal muscle improves insulin action in a rodent m...
Expression of the neuropeptide Y Y1 receptor in human embryo...
May 08, 2013 12:45 PM
The human neuropeptide Y Y1 receptor cDNA was transfected into human embryonic kidney 293 (HEK 293) cells and used to determine the selectivity of newly developed Y1 and Y2 radioligands in a model which expresses a singl...
